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Journal of Pharmacology And Experimental Therapeutics, Vol. 80, Issue 4, 335-342, 1944
Copyright © 1944 by American Society for Pharmacology and Experimental Therapeutics

THE SPASMOLYTIC AND LOCAL ANESTHETIC ACTION OF SOME ESTERS OF 9, 10-DIHYDROANTHRACENE-CARBOXYLIC ACID AND RELATED COMPOUNDS

G. LEHMANN 1 and P. K. KNOEFEL 1

1 From the Department of Pharmacology, University of Louisville School of Medicine, Louisville, Kentucky

The spasmolytic and local anesthetic action and the toxicity of a series of twenty-one basic esters of polynuclear carboxylic acids have been studied.

The diethylaminoethyl ester of xanthene-9-carboxylic acid has the greatest average spasmolytic activity.

The diethylaminoethyl ester of 9, 10-dihydroanthracene-9-carboxylic acid is outstanding for its powerful histamine antagonizing action on smooth muscle. This has been demonstrated on the ileum, on the bronchioles, and to a lesser degree on the blood vessels.

This compound also antagonizes the effect of acetyl-choline and barium on the ileum, and the effect of epinephrine on the uterus, the nictitating membrane, and the blood vessels.

Submitted on November 29, 1943






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Copyright © 1944 by the American Society for Pharmacology and Experimental Therapeutics.