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Journal of Pharmacology And Experimental Therapeutics, Vol. 80, Issue 3, 285-288, 1944
Copyright © 1944 by American Society for Pharmacology and Experimental Therapeutics

CHOLINE ESTERS WITH ATROPINE-LIKE ACTION

KENNETH C. SWAN 1 and N. G. WHITE 1

1 From the Department of Ophthalmology, College of Medicine, State University of Iowa City, Iowa

Surface-active choline esters were prepared by balancing the highly polar quaternary ammonium group in carbamylcholine with non-polar groups at the carbamyl end of the molecule. The new compounds, e.g., di-n-butyl-carbamylcholine chloride, have an atropine-like action on the ocular muscles rather than the muscatine- and nicotine-like effects characterizing previously known choline esters.

Di-n-butyl-carbamylcholine has short action and a proportionately greater effect on accommodation than on the pupil while atropine has more prolonged action and a greater effect on the pupil. The new drugs and atropine act synergistically on the iris sphincter.

Submitted on November 22, 1943






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Copyright © 1944 by the American Society for Pharmacology and Experimental Therapeutics.