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Journal of Pharmacology And Experimental Therapeutics, Vol. 80, Issue 2, 188-192, 1944
Copyright © 1944 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON THE FATE OF MORPHINE SULFURIC ETHER

FRED W. OBERST 1 and E. G. GROSS 2

1 Research Department, U. S. Public Health Service Hospital, Lexington, Kentucky
2 Department of Pharmacology, State University of Iowa, Iowa City, Iowa

The excretion of morphine sulfuric ether, and in some instances its potassium salt, has been studied in 9 non-tolerant and 2 tolerant dogs, and in 2 non-addicts, 1 addict, and 10 post-addicts. It is excreted in urine as both free and bound morphine, the amounts of which are somewhat lower than that reported for morphine per se.

Its pharmacological activity is of a low order; it does not produce euphoria in man or relieve pain. Neither can it be substituted for morphine in addicts nor does it relieve withdrawal symptoms. Its pain-threshold raising effect as determined by Hardy, Wolff, and Goodell technique is practically absent in man and is questionable in dogs.

Submitted on November 15, 1943






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Copyright © 1944 by the American Society for Pharmacology and Experimental Therapeutics.