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Journal of Pharmacology And Experimental Therapeutics, Vol. 80, Issue 2, 171-175, 1944
Copyright © 1944 by American Society for Pharmacology and Experimental Therapeutics

A CONTRIBUTION TO THE PHARMACOLOGY OF THE NITRATE ESTER OF CHOLINE PERCHLORATE

C. JELLEFF CARR 1, FREDERICK K. BELL 1, WILLIAM E. EVANS JR. 1, and JOHN C. KRANTZ JR. 1

1 Department of Pharmacology, School of Medicine, University of Maryland, Baltimore, Md.

1. The nitrate ester of choline perchlorate is a stable inorganic acid ester which mimics many of the pharmacological responses of acetylcholine.

2. Its depressor potency is approximately one-hall that of acetylcholine. Its depressor effect is obliterated by atropine but not affected by the choline esterase.

3. This ester is approximately ten times as toxic to the rat as is acetylcholine.

4. It is possible that this simple choline ester may find application in therapeutics as a parasympathomimetic drug.

Submitted on November 3, 1943






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Copyright © 1944 by the American Society for Pharmacology and Experimental Therapeutics.