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Journal of Pharmacology And Experimental Therapeutics, Vol. 80, Issue 2, 132-138, 1944
Copyright © 1944 by American Society for Pharmacology and Experimental Therapeutics

TISSUE ALDEHYDES AND THEIR REACTION WITH AMINES

KURT A. OSTER 1 and MICHAEL G. MULINOS 1

1 From the Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York

1. The staining reaction for aldehydes with fuchsin sulfurous acid is described for liver and kidney tissues of 5 species of animals.

2. The formation of condensation products (Schiff's base) between tissue aldehydes and various amines and the influence of hydrogen ion concentration is described.

3. The significance of the formation of Schiff's base as a detoxification mechanism and the interference of p-amino benzoic acid with the antiseptic powers of the sulfonamides is discussed.

Submitted on October 13, 1943






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Copyright © 1944 by the American Society for Pharmacology and Experimental Therapeutics.