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Journal of Pharmacology And Experimental Therapeutics, Vol. 80, Issue 1, 81-92, 1944
Copyright © 1944 by American Society for Pharmacology and Experimental Therapeutics

THE DETOXICATION OF NEOARSPHENAMINE BY MEANS OF VARIOUS ORGANIC ACIDS

E. W. McCHESNEY 1, O. W. BARLOW 1, and G. H. KLINCK JR. 1

1 From the Research Laboratories, Winthrop Chemical Co., Inc., Rensselaer, N. Y., and the Department of Pathology, Samaritan Hospital, Troy, N. Y.

The toxicity of neoarsphenamine for albino rats is materially reduced by ascorbic, isoascorbic, d-glucoascorbic, and p-aminobenzoic acids. The most favorable effect is obtained if the arsenical and protective agent are injected intravenously in the same solution, but the acids are somewhat effective if injected simultaneously at another site. The function of the ascorbic acids appears to be primarily that of preventing oxidation, chiefly after injection. The mechanism by which p-aminobenzoic acid reduces toxicity is obviously different and has been discussed elsewhere (10). There is evidence that the therapeutic efficiency of some typical arsenicals is not altered by the detoxicants.

Submitted on October 11, 1943




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J. C. FINERTY and J. D. GRACE
DETOXICATION OF ARSENIC TRIOXIDE BY ORAL ADMINISTRATION OF FLUORIDES
Science, April 6, 1945; 101(2623): 359 - 360.
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Copyright © 1944 by the American Society for Pharmacology and Experimental Therapeutics.