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Journal of Pharmacology And Experimental Therapeutics, Vol. 80, Issue 1, 31-38, 1944
Copyright © 1944 by American Society for Pharmacology and Experimental Therapeutics

METHEMOGLOBINEMIA AFTER ADMINISTRATION OF p-AMINOACETOPHENONE AND p-AMINOPROPIOPHENONE

J. M. VANDENBELT 1, CARL PFEIFFER 1, MARGARET KAISER 1, and MARGARET SIBERT 1

1 From the Research and Biological Laboratories, Parke, Davis & Co., Detroit, Mich.

The compounds, p-aminoacetophenone and p-aminopropiophenone, whether given orally or intravenously, are highly active in forming methemoglobin. The latter is the more active, being as active as p-dinitrobenzene, but differing in that its effect is less rapid and more prolonged. Death occurs at 95% methemoglobinemia and recovery may occur with 87% methemoglobinemia. Due to the desirable chemical and pharmacological properties of p-aminopropiophenone this compound may prove of value for the experimental production of methemoglobinemia and anoxia.

Submitted on August 19, 1943






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Copyright © 1944 by the American Society for Pharmacology and Experimental Therapeutics.