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Journal of Pharmacology And Experimental Therapeutics, Vol. 80, Issue 1, 1-7, 1944
Copyright © 1944 by American Society for Pharmacology and Experimental Therapeutics

VASCULAR FRAGILITY AND PERMEABILITY AS INFLUENCED BY VARIOUS AGENTS

I. A DESCRIPTION OF AN EXPERIMENTAL METHOD AND OF THE EFFECTS OF VARIOUS SUBSTANCES RELATED TO VITAMIN P

GEORGE J. MAJOVSKI 1, A. J. LESSER 1, HOMER C. LAWSON 1, HERBERT O. CARNE 1, and C. H. THIENES 1

1 Department of Pharmacology, School of Medicine, University of Southern California, Los Angeles

A method has been developed which can be used to show the protective action of certain citrus peel fractions ("vitamin P") in controlling vascular fragility. When air is suddenly evacuated from a jar in which mice are placed, hemorrhage occurs into the lungs of these mice. Crude hesperidin obtained from oranges, and a water soluble extract of lemon peel afforded protection to mice against this hemorrhage for a period of 2 to 4 hours after administration. Pure hesperidin had little or no protective effect, but during the first 2 hours following its administration, a greater degree of hemorrhage was apparent.

Submitted on July 15, 1943






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