JPET Celsis microsomes equal better data

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Journal of Pharmacology And Experimental Therapeutics, Vol. 79, Issue 4, 354-363, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON SULFAPYRAZINE

HARRY J. ROBINSON 1, HENRY SIEGEL 1, and OTTO E. GRAESSLE 1

1 From the Merck Institute for Therapeutic Research, Rahway, New Jersey

1. Rats receiving sulfapyrazine or sulfadiazine revealed the same qualitative pathological changes following prolonged administration.

2. The incidence of urolith formation following the administration of sulfadiazine and sulfapyrazine can be greatly reduced or completely eliminated by alkalization of the urine.

3. Sulfapyrazine and sulfadiazine appear to be equally effective against experimental pneumococcal, streptococcal, and staphylococcal infections when compared on the basis of equal blood concentrations.

Submitted on August 17, 1943






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Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.