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Journal of Pharmacology And Experimental Therapeutics, Vol. 79, Issue 4, 281-285, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

THE METABOLISM OF PARALDEHYDE

I. THE DETERMINATION OF PARALDEHYDE IN TISSUES, BLOOD AND EXPIRED AIR

PHILIP HITCHCOCK 1 and ERWIN E. NELSON 1

1 Department of Pharmacology, The Tulane University of Louisiana School of Medicine, New Orleans, La.

Methods for the determination of paraldehyde in blood, tissues and expired air are described. The determination in blood is accomplished by means of the color reaction between paraldehyde and p-hydroxydiphenyl in sulfuric acid; the estimations in tissues and expired air are performed by depolymerization of the paraldehyde to acetaldehyde in hot dilute sulfuric acid and absorption of the liberated acetaldehyde in sodium bisulfite solution, followed by iodometric titration. The methods have an accuracy of about 5 per cent.

Submitted on May 31, 1943






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Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.