JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow A correction has been published
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by WOOD, D. R.
Right arrow Articles by JACO, N. T.
Right arrow Search for Related Content
PubMed
Right arrow Articles by WOOD, D. R.
Right arrow Articles by JACO, N. T.
Journal of Pharmacology And Experimental Therapeutics, Vol. 79, Issue 3, 259-265, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF HAEMORRHAGE ON ANAESTHETIC DOSAGE

D. R. WOOD 1 and N. T. JACO 1

1 From the Department of Pharmacology, Oxford, England

1. Experiments have been performed to show the effect of haemorrhage on anaesthetic dosage in animals.

2. The intravenous dose of pentobarbitone required to produce an arbitrarily defined level of anaesthesia in rabbits was not significantly reduced by haemorrhage of 15 c.c./kg., but a reduction of 18% was observed after the loss of 20 c.c./kg. This degree of haemorrhage reduced the dose producing respiratory failure by 24%, but the safety ratio was not altered.

3. Induction of ether anaesthesia in rats was more rapid after haemorrhage. Loss of more than 25% of the blood volume reduced the induction time to 60, 65 and 75% of the normal time in ether concentrations of 7, 8 and 9%. Anaesthesia could be maintained in 50% of the bled rats by an ether concentration of 3 to 4%, while 5 to 6% ether was required to maintain anaesthesia in 50% of normal rats.

4. Recovery times after pentobarbitone anaesthesia in rabbits and after ether anaesthesia in rats were not significantly altered by haemorrhage.

Submitted on August 2, 1943






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.