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Journal of Pharmacology And Experimental Therapeutics, Vol. 79, Issue 3, 240-245, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON SHOCK INDUCED BY HEMORRHAGE

V. THE EFFECT OF CELLULAR DAMAGE ON THE IN VITRO HYDROLYSIS AND SYNTHESIS OF COCARBOXYLASE BY LIVER TISSUE

WM. M. GOVIER 1 and MARGARET E. GREIG 1

1 From the Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee

1. The synthesis and hydrolysis of cocarboxylase by pigeon and rat liver in several states of dispersion have been investigated.

2. Ochoa's observations, that pigeon liver slices and homogenate can synthesize cocarboxylase from thiamin aerobically and that the same tissue dephosphorylates cocarboxylase anaerobically, have been confirmed.

3. The addition of pyrophosphate with thiamin to liver tissue may result in synthesis of cocarboxylase greater than that which occurs on the addition of thiamin alone.

4. The amount of hydrolysis of cocarboxylase by liver tissue varies directly with the severity of damage to the tissue.

Submitted on July 26, 1943




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W. H. FISHMAN and WM. M. GOVIER
THE CHANGES IN RAT KIDNEY COCARBOXYLASE ASSOCIATED WITH THE INJURIOUS EFFECTS OF dl-SERINE
Science, March 16, 1945; 101(2620): 277 - 279.
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Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.