EFFECT OF ORAL ADMINISTRATION OF SUCCINYL SULFAPYRAZINE ON BACTERIAL (COLIFORM) FLORA OF THE INTESTINE OF NORMAL MICE

¹ From the Research Institute of Cutaneous Medicine, Dr. John A. Kolmer, Director, Philadelphia, Pa.
² From the Dermatological Research Laboratories, Philadelphia, Pa., Division of Abbott Laboratories, Chicago, Ill.

The bactericidal action of two new sulfonamide derivatives, i.e., succinyl sulfapyrazine and malyl sulfathiazole, against the intestinal coliform flora of normal mice was determined and compared with the action of sulfaguanidine and sulfasuxidine (succinyl sulfathiazole). Under the conditions of our experiments, succinyl sulfapyrazine proved highly effective and at least equal to sulfaguanidine in diminishing the density of coliform bacteria in the contents of the intestine of normal mice. Its bactericidal effectiveness was much greater than that of sulfasuxidine and greater than that of malyl sulfathiazole. This last compound proved about equal in its effectiveness to sulfasuxidine.

The toxicity of succinyl sulfapyrazine, sulfaguanidine and sulfasuxidine (succinyl sulfathiazole) proved to be very low for mice when administered in large quantities in acacia suspension or in a drug diet. The resulting blood levels in mice on one per cent. drug food mixture were generally low for all three drugs, with succinyl sulfapyrazine somewhat higher than the other two drugs.

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