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Journal of Pharmacology And Experimental Therapeutics, Vol. 79, Issue 2, 176-178, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF ENVIRONMENTAL TEMPERATURE ON THE TOXICITY OF 2,4-DINITROPHENOL IN MICE

GERALDINE J. FUHRMAN 1, FRANK W. WEYMOUTH 1, and JOHN FIELD 2D 1

1 Department of Physiology, Stanford University

1. It is shown that the toxicity of 2,4-dinitrophenol in the adult albino mouse is lowered by decrease and raised by increase of environmental temperature between 6° and 40°C.

2. Calculated values of the LD50, for DNP in mgm. per kgm. were 35.7 and 30.9 at 6° and 25° respectively. The difference between these values is significant

3. The LD50 at 40°C. was not determined. However, it is shown that it lies below 8.22 mgm. DNP per kgm. and is significantly lower than the 25°C. value.

Submitted on July 15, 1943






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Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.