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Journal of Pharmacology And Experimental Therapeutics, Vol. 79, Issue 2, 169-175, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON SHOCK INDUCED BY HEMORRHAGE

IV. THE DEPHOSPHORYLATION OF COCARBOXYLASE IN TISSUES DURING SHOCK AND ANOXIA

MARGARET E. GREIG 1 and WM. M. GOVIER 1

1 From the Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee

1. The cocarboxylase content of tissues of normal dogs, dogs in which shock has been induced by hemorrhage, and in animals in anoxic anoxia has been investigated.

2. In shock and in anoxic anoxia a dephosphorylation of cocarboxylase occurs.

3. In dogs subjected to hemorrhage thiamin therapy results in a resynthesis of cocarboxylase

Submitted on July 15, 1943






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Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.