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Journal of Pharmacology And Experimental Therapeutics, Vol. 79, Issue 2, 164-168, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

SOME PHARMACOLOGICAL ACTIONS OF ADENINE-THIOMETHYLPENTOSE

P. L. EWING 1 and F. SCHLENK 1

1 From the Departments of Pharmacology and Preventive Medicine and Public Health School of Medicine, University of Texas, Galveston

1. Some pharmacological actions of adenine-thiomethylpentose, a naturally occurring nucleoside, were studied.

2. Qualitatively its actions are similar to those of other nucleic acid derivatives of this class, i.e., lowering of the blood pressure in rabbits, relaxation of rabbit intestinal strips and contraction of the isolated guinea pig uterus.

3. Quantitatively, it is much weaker than adenosine in increasing blood pressure and relaxing intestinal muscle and approximately equal to adenosine in contracting the guinea pig uterus.

4. Adenosine deaminase does not attack adenine-thiomethylpentose. The significance of this finding in relation to the pharmacological activity is discussed.

Submitted on July 15, 1943






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