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Journal of Pharmacology And Experimental Therapeutics, Vol. 79, Issue 2, 136-139, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF URINARY pH ON THE ELIMINATION OF QUININE IN MAN

H. B. HAAG 1, P. S. LARSON 1, and J. J. SCHWARTZ 1

1 Department of Pharmacology, Medical College of Virginia, Richmond

When quinine was given in a dose of 500 mg. orally to human subjects, it was found that the extent of urinary elimination was related to the pH of the urine. When the urine was maintained alkaline one-half as much quinine, on an average, was eliminated as when the urine was acid (8.9 vs. 17.4%). This difference is assumed to be due to greater resorption of quinine from the urinary tract when the urine is alkaline than when the urine is acid.

Although the amount of quinine "saved" to the patient is small on alkalinization of the urine, this saving plus the advantages of an alkaline regime suggested by clinical investigators on the basis of other types of observations, seem to recommend further consideration of the use of alkalies in the quinine therapy of malaria.

These experiments again indicate the importance of considering the possible influence of urinary pH in quantitative studies on the urinary excretion of certain chemicals.

Submitted on July 1, 1943




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Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.