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Journal of Pharmacology And Experimental Therapeutics, Vol. 79, Issue 2, 111-116, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

INFLUENCE OF SODIUM BISULFITE ON THE TOXICITY OF EPINEPHRINE

RICHARD K. RICHARDS 1

1 Dept. of Pharmacology, Abbott Laboratories, North Chicago, Illinois

1. The addition of sodium bisulfite (0.1 to 1.0%) greatly enhances the subcutaneous and intramuscular toxicities of epinephrine HCl solutions in rats, mice, rabbits, and dogs. The intravenous toxicity remains uninfluenced.

2. The increase of epinephrine effects by the addition of sodium bisulfite was also demonstrated in non-toxic doses on the blood sugar curve of dogs.

3. Evidence has been brought forward that this effect is due to a local increase of the speed of absorption produced by sodium bisulfite. A number of other reducing and acidifying agents have been found practically devoid of this action in comparative concentrations. Mention has been made of a similar effect of sodium bisulfite upon a few other drugs.

Submitted on June 21, 1943






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Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.