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Journal of Pharmacology And Experimental Therapeutics, Vol. 79, Issue 1, 32-36, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

A COMPARISON OF THE MECHANISM OF ACTION OF ARSENICALS AND SULFONAMIDES

LAWRENCE PETERS 1

1 From the Department of Pharmacology, Medical-Research Division, Sharp and Dohme, Inc., Glenolden, Pa.

The mode of action of sodium p-aminophenylarsonate (atoxyl) on E. coli appears to be similar to that of sulfonamides, since the same mechanisms of antagonism appear to be involved.

The bacteriostatic and trypanocidal activities of m-amino-p-hydroxyphenylarsenoxide, `Mapharsen,' apparently are exerted through a different mechanism than that which is involved in the bacteriostatic action of sulfonamides.

Submitted on May 15, 1943






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Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.