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Journal of Pharmacology And Experimental Therapeutics, Vol. 79, Issue 1, 16-22, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

INCREASED BLOOD SPECIFIC GRAVITY IN ANESTHETIZED DOGS FOLLOWING PILOCARPINE INJECTIONS

BUFORD H. BURCH 1 and B. A. WESTFALL 1

1 From the Department of Physiology and Pharmacology, University of Missouri, Columbia

1. The specific gravity of blood of dogs lying quietly under sodium pentobarbital anesthesia (32.5 mgm./kgm.) rises gradually.

2. Pilocarpine nitrate (0.2 mgm./kgm.) when administered to dogs in deep pentobarbital anesthesia produces a rapid increase in the specific gravity of the blood, the maximal rise being five minutes after the injection of the drug.

3. The spleen, the kidneys and the intestines collectively contribute in the production of this rise in blood specific gravity following injection of pilocarpine into anesthetized dogs.

4. No evidence that the posterior pituitary gland is involved in this rise in blood specific gravity following injections of pilocarpine was obtained during these experiments.

Submitted on May 6, 1943






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Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.