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Journal of Pharmacology And Experimental Therapeutics, Vol. 79, Issue 1, 10-15, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

A METHOD FOR THE DETERMINATION OF DEMEROL IN URINE AND RESULTS OF ITS APPLICATION

FRED W. OBERST 1

1 From the United States Public Health Service Hospital, Lexington, Kentucky

1. A method for the determination of Demerol in urine is described.

2. The per cent of Demerol excreted in the urine of post-addicts not requiring an analgetic receiving 300 to 800 mgm. Demerol per day varied between 2.2 and 21.2. The average for 273 analyses was 9.1%. Tolerance was not a factor affecting Demerol excretion.

3. The average per cent excretion of Demerol after single doses of 100 mgm. was, after 24 hours, about the same as in patients receiving daily multiple doses varying from 300 to 800 mgm. About 72% of the total amount of detectable Demerol in urine is excreted within 7 hours after a dose.

Submitted on April 28, 1943






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Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.