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Journal of Pharmacology And Experimental Therapeutics, Vol. 79, Issue 1, 1-4, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

INFLUENCE OF ADDITION OF CHLORINE TO THE SIDE CHAIN ON CERTAIN ACTIONS OF ACETYLCHOLINE

JAMES L. MORRISON 1

1 Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia

Introduction of chlorine into the acetyl group of acetylcholine greatly reduces its muscarinic effect on blood pressure and slightly reduces its toxicity for white mice. Chloroacetylcholine chloride does not give a positive chromodacryorrhea test.

Submitted on January 4, 1943






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Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.