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Journal of Pharmacology And Experimental Therapeutics, Vol. 78, Issue 4, 394-399, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

THE CONJUGATION IN VITRO OF PHENOL BY GUINEA PIG LIVER

FREDERICK BERNHEIM 1 and MARY L. C. BERNHEIM 1

1 From the Departments of Physiology and Pharmacology and Biochemistry, Duke University School of Medicine, Durham, North Carolina

1. Phenol disappears when added to guinea pig liver slices in Ringer bicarbonate solution shaken at 37° in 95% oxygen 5% carbon dioxide. 20-30% of the amount that disappears is conjugated.

2. Thermolabile enzyme systems are responsible for the disappearance and conjugation. Neither process occurs anaerobically. The effects of the amount of tissue and substrate concentration are described.

3. In the absence of added sulfate no conjugation occurs. Cystine or methionine cannot act as sources of sulfate under the experimental conditions.

4. M/300 cocaine HCl inhibits the disappearance of phenol but has no effect on the percentage conjugated.

Submitted on April 21, 1943




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