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Journal of Pharmacology And Experimental Therapeutics, Vol. 78, Issue 4, 386-393, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

THE REDUCTION OF 2,4,6-TRINITROTOLUENE BY ANIMAL TISSUE IN VITRO

BENTON B. WESTFALL 1

1 From the Division of Chemotherapy, National Institute of Health, Bethesda, Maryland

1. It has been shown that extracts of animal tissues have the power of reducing symmetrical trinitrotoluene in vitro. At least a portion of the resulting product or products behaved as a diazotizable amino compound.

2. This reducing power was very largely destroyed by heating to 80°C. for 10 minutes. It was augmented by anaerobic conditions and very largely inhibited by oxygenation.

3. The reducing effect was partially removed by washing and restored by added succinate and discharged again by malonate.

4. These facts were interpreted as indicative of the presence of an enzyme concerned in the reduction.

Submitted on April 21, 1943






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Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.