JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by HARRIS, P. N.
Right arrow Articles by CHEN, K. K.
Right arrow Search for Related Content
PubMed
Right arrow Articles by HARRIS, P. N.
Right arrow Articles by CHEN, K. K.
Journal of Pharmacology And Experimental Therapeutics, Vol. 78, Issue 4, 372-374, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

THE ACTION OF RIDDELLINE

PAUL N. HARRIS 1, ROBERT C. ANDERSON 1, and K. K. CHEN 1

1 From the Lilly Research Laboratories, Eli Lilly and Company, Indianapolis

1. The acute toxicity of riddelline has been determined in mice by intravenous injection.

2. Like other Senecio alkaloids so far studied, riddelline produces in mice central necrosis of the liver, ascites or hydrothorax, and pulmonary edema. There is also evidence of necrosis of cortical lymphocytes in the thymus.

3. Riddelline inhibits the isolated rabbit's small intestine and stimulates the isolated guinea pig's uterus. It causes a fall of blood pressure when injected by vein in pithed or barbitalized cats.

Submitted on April 16, 1943






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.