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Journal of Pharmacology And Experimental Therapeutics, Vol. 78, Issue 4, 366-371, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

THE FATE OF SULFONAMIDES AND p-AMINOBENZOIC ACID IN COLD-BLOODED ANIMALS

ROBERT B. FAILEY JR. 1, ROBERT C. ANDERSON 1, FRANCIS G. HENDERSON 1, and K. K. CHEN 1

1 From the Lilly Research Laboratories, Eli Lilly and Company, Indianapolis

1. Sulfanilamide, sulfapyridine, sulfathiazole, sulfadiazine, or p-aminobenzoic acid, in the form of the sodium salt, when injected into the ventral lymph sac of the spadefoot toad (Scaphiopus holbrookii holbrookii), or the nebulous toad (Bufo valliceps), is partly conjugated as shown in blood and urine. The degree of conjugation as observed in blood is apparently not as great as in the rabbit. In the nebulous toad's blood, the conjugated form of sulfadiazine is unmeasurable.

2. Similarly, conjugation takes place in the tree frog (Hyla cinerea cinerea) with sulfanilamide, sulfapyridine, sulfathiazole, and sulfadiazine.

3. Confirmatory of Marshall's work, sulfanilamide, sulfapyridine, and sulfathiazole are found to be unconjugated in the Leopard frog (Rana pipiens) and the "Jumbo" bullfrog (Rana catesbeiana). Also, sulfadiazine and p-aminobenzoic acid are not conjugated in the former animal.

4. No conjugation takes place in the turtle (Pseudemys elegans) with sulfanilamide, sulfapyridine, sulfadiazine, or p-aminobenzoic acid. There is, however, a slight conjugation with sulfathiazole.

Submitted on April 16, 1943






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Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.