JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by GROSS, E. G.
Right arrow Articles by CULLEN, S. C.
Right arrow Search for Related Content
PubMed
Right arrow Articles by GROSS, E. G.
Right arrow Articles by CULLEN, S. C.
Journal of Pharmacology And Experimental Therapeutics, Vol. 78, Issue 4, 358-365, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECTS OF ANESTHETIC AGENTS ON MUSCULAR CONTRACTION

E. G. GROSS 1 and STUART C. CULLEN 1

1 From the Department of Pharmacology and the Division of Anesthesiology, Department of Surgery, College of Medicine, State University of Iowa, Iowa City

From the observations recorded in this investigation, it can only be said that (1) the contraction of the gastrocnemius muscle which is elicited by intraarterially injected acetylcholine or electrical stimulation of the nerve is less pronounced in (dogs anesthetized with ether, tribromethanol, and sodium pentothal than in dogs anesthetized with cyclopropane or ethylene, (2) prostigmine potentiates the contraction response in the dog anesthetized with cyclopropane and ether, and (3) the difference in contraction during anesthesia with the various agents is not altered by sectioning the nerve supply to the muscle.

It seems likely, therefore, that the interference with the contraction is located in the humoral mechanism of transmission of nerve impulses, and that ether, tribromethanol, and sodium ethyl (l methyl-butyl) thiobarbiturate (Sodium Pentothal) can be said to have a curariform action. Of these three, ether causes the greatest interference; tribromethanol and sodium pentothal do so only in very high blood concentrations.

The clinical difficulties encountered with the concomitant use of ether and curare are thus accounted for.

Submitted on April 16, 1943






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.