STUDIES ON THE DETOXICATION OF ORGANIC ARSENICAL COMPOUNDS

III. THE TIME-FACTOR INFLUENCING p-AMINOBENZOATE PROTECTION OF RATS RECEIVING LETHAL DOSES OF PHENYL ARSONATES

¹ Lilly Research Laboratories, Indianapolis, Indiana

1. The time factor entering into the sequence of administering uniform doses of p-aminobenzoate and either of two typical phenyl arsonic acid derivatives to rats is found significantly to influence the survival rate of the group.

2. The prior injection of p-aminobenzoate up to three hours before the arsenical confers protection upon nearly all animals. In contrast, the injection of the arsenical thirty minutes before the p-aminobenzoate is associated with a distinct reduction in the group (or overall) protection, and this reduction proceeds pari passu with the increase in the time interval.

3. An explanation of this phenomenon in terms of the in-vivo reduction of pentavalent arsenicals to the trivalent "arsenoxides" is tentatively presented.

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