STUDIES ON THE DETOXICATION OF ORGANIC ARSENICAL COMPOUNDS

II. CORRELATION OF THE QUANTITY OF p-AMINOBENZOIC ACID REQUIRED TO PROTECT RATS AGAINST HIGH DOSES OF CARBARSONE AND ARSANILIC ACID

¹ From the Lilly Research Laboratories, Indianapolis, Indiana

1. By the administration of sufficient p-aminobenzoate, essentially all rats may be protected against a "Universal Lethal Dose" (LD₁₀₀) of such phenyl arsonates as carbarsone and arsanilic acid (= `Atoxyl'). Beyond this arsenical dose level, there is a gradual decrease in the group survival rate.

2. A single injection of p-aminobenzoate is capable of conferring the protection.

3. Against the LD₉₀ quantity of these pentavalent arsenicals, protection is afforded by a relatively smaller dose of p-aminobenzoate; 15 mgm./kg. was found sufficient to protect 50% of individual rats and to prolong the survival time of a group of rats receiving 400 mgm./kg. of arsanilic acid.