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Journal of Pharmacology And Experimental Therapeutics, Vol. 78, Issue 2, 174-179, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

FURTHER STUDIES ON THE SEPARATION FROM KIDNEY TISSUE OF A SUBSTANCE CAPABLE OF REDUCING THE BLOOD PRESSURE IN EXPERIMENTALLY INDUCED HYPERTENSION

ARTHUR GROLLMAN 1 and T. R. HARRISON 1

1 From the Department of Internal Medicine, Bowman Gray School of Medicine of Wake Forest College, Winston-Salem, N. C.

Procedures are outlined for fractionating and concentrating renal extracts which, in relatively small doses administered orally, effectively reduce the blood pressure of hypertensive rats. The solubility of the active principle in water and aqueous solutions of organic solvents and the behavior of the extracts toward various precipitants (picric acid, ammonium sulfate, etc.) are described. The dialyzability of the active principle differentiates it from the agent described by other workers as effective following parenteral administration.

Submitted on January 15, 1943






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Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.