JPET Celsis microsomes equal better data

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Journal of Pharmacology And Experimental Therapeutics, Vol. 78, Issue 2, 170-173, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

A POSSIBLE METHOD FOR THE DETERMINATION OF PROLONGED ACTION OF BARBITURATES

VERSA V. COLE 1

1 From the Department of Pharamacology of Woman's Medical College of Pennsylvania, and the Department of Biochemistry and Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana

(1) Sodium pentobarbital was effective against deaths from strychnine and picrotoxin hours after the signs of narcosis are no longer present.

(2) Sodium phenobarbital was more effective against deaths from strychnine when given 22 hours before the strychnine than when given 20 minutes before strychnine.

(3) Sodium phenobarbital was equally effective against deaths from picrotoxin whether given 20 minutes or 22 hours before picrotoxin.

Submitted on November 25, 1942






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Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.