JPET Celsis microsomes equal better data

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by SEELER, A. O.
Right arrow Articles by MALANGA, C.
Right arrow Search for Related Content
PubMed
Right arrow Articles by SEELER, A. O.
Right arrow Articles by MALANGA, C.
Journal of Pharmacology And Experimental Therapeutics, Vol. 78, Issue 2, 159-163, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

THE COMPARATIVE ACTIVITY OF QUININE, QUINIDINE, CIN-CHONINE, CINCHONIDINE AND QUINOIDINE AGAINS PLASMODIUM LOPHURAE INFECTIONS OF PEKIN DUCKLINGS

A. O. SEELER 1, E. DUSENBERY 1, and C. MALANGA 1

1 From the Merck Institute for Therapeutic Research, Rahway, N. J.

1. Quinine, quinidine, cinchonine and cinchonidine show about the same activity against the schizonts of P. lophurae in Pekin ducklings.

2. Quinoidine is considerably less active than the four crystalline cinchona alkaloids.

3. Two samples of totaquine varying widely in their quinine content were as active as quinine in duck malaria.

4. There is little difference in the acute oral toxicity for mice among the four crystalline alkaloids. Quinoidine is more toxic than the crystalline alkaloids.

Submitted on March 23, 1943






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.