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Journal of Pharmacology And Experimental Therapeutics, Vol. 78, Issue 2, 154-158, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

THE ESTIMATION OF QUININE IN HUMAN PLASMA WITH A NOTE ON THE ESTIMATION OF QUINIDINE

BERNARD B. BRODIE 1 and SIDNEY UDENFRIEND 1

1 From The Research Service, Third (N. Y. U.) Medical Division, The Goldwater Memorial Hospital, Welfare Island, N. Y.; and Department of Medicine, New York University College of Medicine

A simple precise method is described for the estimation of quinine in human plasma. The proteins of these fluids are precipitated with metaphosphoric acid and the quinine concentration in the filtrate assayed by measuring the intensity of its fluorescence in ultraviolet light. An identical procedure may be used for the estimation of quinidine in plasma.

Submitted on March 20, 1943




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Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.