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Journal of Pharmacology And Experimental Therapeutics, Vol. 78, Issue 2, 109-114, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON THE DETOXICATION OF ORGANIC ARSENICAL COMPOUNDS

I. DETOXICATION BY MEANS OF p-AMINOBENZOIC ACID OF CERTAIN PENTAVALENT ARSENICAL DRUGS GIVEN IN MASSIVE DOSES TO RATS

J. H. SANDGROUND 1 and CHARLES R. HAMILTON 1

1 From the Lilly Research Laboratories, Indianapolis, Indiana

1. p-aminobenzoic acid has been found highly effective in reducing fatalities among rats to which high, acutely poisonous doses of Carbarsone, Acetarsone, "Tryparsamide", arsanilic acid, and phenyl arsonic acid have been administered. No close structural similarity exists between these several phenyl arsonates and p-aminobenzoic acid.

2. Detoxication is independent of the route whereby either the phenyl arsonic compound or the p-aminobenzoic acid is given.

3. No inhibition by p-aminobenzoic acid of the trypanocidal action of Carbarsone, "Tryparsamide" or arsanilic acid (= "Atoxyl") was detected in rats infected with Trypanosoma equiperdum.

Submitted on February 26, 1943




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Arch Intern Med, November 1, 1943; 72(5): 635 - 706.
[Abstract] [PDF]


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Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.