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Journal of Pharmacology And Experimental Therapeutics, Vol. 78, Issue 1, 79-89, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

THE CHEMICAL NATURE OF COMPOUNDS WHICH INHIBIT THE FUNCTION OF THE THYROID GLAND

E. B. ASTWOOD 1

1 From the Departments of Pharmacology and Medicine, Harvard Medical School, Boston, Massachusetts

The relative effectiveness of 106 chemical compounds in inhibiting the function of the thyroid gland was tested in young rats. When these substances were administered in the food or drinking water for a period of ten days, the degree of thyroid hyperplasia, as estimated by gross and microscopic examination, provided an estimate of their activity.

Two classes of compounds were found to be active: thiourea derivatives and certain derivatives of aniline. The compounds more effective than thiourea in decreasing order of activity were : 2-thiouracil, 2-thiobarbituric acid, sym.-diethylthiourea and 5-benzal-2-thiohydantoin. The effective aniline derivatives comprised the sulfonamides, p-, m-, o-aminobenzoic acids, p-aminophenylacetic acid and p-aminoacetanilide. Thiocyanates were found to cause thyroid enlargement only in the absence of added iodide, while organic cyanides failed to influence the thyroid gland.

Submitted on February 8, 1943




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