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Journal of Pharmacology And Experimental Therapeutics, Vol. 78, Issue 1, 100-107, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

ANTIPRESSOR EFFECTS OF ORTHOQUINOID EPINEPHRINE DERIVATIVES IN EXPERIMENTAL HYPERTENSION IN THE RAT

KURT A. OSTER 1 and HARRY SOBOTKA 1

1 From the Department of Chemistry, Laboratories of the Mount Sinai Hospital, New York

Adrenochrome derivatives when administered parenterally lower the blood pressure of experimentally hypertensive rats but do not affect the blood pressure of normal animals. No toxic manifestations or fever are observed. The halogeno-adrenochromes fulfill for the rat the requirements postulated for an antipressor drug.

Acute experiments eliminate as explanation of the observed effects a parasympathomimetic, direct muscular or sympatholytic mechanism.

The catabolism of pressor amines is discussed and a chemical mechanism for the antipressor effect of quinones is suggested with due regard to species differences.

Submitted on February 15, 1943




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Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.