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Journal of Pharmacology And Experimental Therapeutics, Vol. 77, Issue 4, 332-335, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

THE ACTION OF ADRENALINE UPON THE ATROPINE-ACETYL CHOLINE REVERSAL PHENOMENON

R. L. STEHLE 1 and K. I. MELVILLE 1

1 From the Department of Pharmacology, McGill University, Montreal, Canada

1. During intravenous infusion of adrenaline or arterenol in the atropinized spinal cat, the pressor response to a large dose of acetyl choline is abolished and a transient depressor response noted.

2. During intravenous infusion of posterior pituitary extract under similar conditions the pressor response to acetyl choline is not abolished but may be preceded by a transient depressor response when the blood pressure level is high.

3. These results are in agreement with those of Marazzi and Bülbring and Burn, which show that adrenaline depresses ganglionic sympathetic transmission. Arterenol also exerts a similar action.

4. Possible mechanisms of the transient depressor effects of a large dose of acetyl choline as observed in the above experiments are discussed.

Submitted on February 18, 1943






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Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.