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Journal of Pharmacology And Experimental Therapeutics, Vol. 77, Issue 3, 274-276, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF COCAINE ON THE EXCRETION OF PHENOL

CLARA TORDA 1

1 From the Department of Pharmacology, Cornell University Medical College, New York City

1. The effect of cocaine on the phenol elimination of fasting cats has been investigated.

2. Cocaine alone does not significantly modify the phenol elimination.

3. Non-cocainized cats eliminate the injected phenol during the first 24 hours.

4. Cocainized cats do not show any significant increase in the elimination of phenol in the urine after injection of phenol, indicating that cocaine inhibits the enzymatic processes involved in the esterification of phenols in vivo.

5. This evidence of enzyme inhibition is a further indication of the possibility of the inactivation of epinephrine by esterification of the phenol ring.

Submitted on November 20, 1942






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Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.