JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by ANDERSON, W. F.
Right arrow Articles by MORRIS, N.
Right arrow Search for Related Content
PubMed
Right arrow Articles by ANDERSON, W. F.
Right arrow Articles by MORRIS, N.
Journal of Pharmacology And Experimental Therapeutics, Vol. 77, Issue 3, 258-265, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECTS OF ATROPINE, PROSTIGMIN, ADRENALINE AND CALCIUM ON THE MOVEMENTS OF THE FASTING HUMAN STOMACH

W. FERGUSON ANDERSON 1 and NOAH MORRIS 1

1 From the Department of Materia Medica and Therapeutics, University of Glasgow, and Stobhill Hospital, Glasgow, Scotland

The action of various drugs on the motility of the fasting stomach in man is recorded.

1. Atropine in small doses has a parasympathomimetic action causing an increase in the frequency and amplitude of the hunger contractions and a slowing of the pulse-rate. This dosage has also a sensitising effect whereby an antiparasympathetic action is obtained from a second small dose. In large doses atropine inhibits the movements of the stomach and quickens the heart-rate.

2. Prostigmin has been shown to have excitor effect on gastric motility. Premedication with atropine does not change this action. If given in large doses, however, the atropine may prevent the stimulating effect of the prostigmin. The effects of atropine are not altered by previous administration of prostigmin.

3. Adrenaline in very small doses occasionally appears to increase gastric motility. Large doses constantly have a sedative action.

4. Calckim has a sedative action on the fasting contractions of the stomach and slows the pulse-rate.

Submitted on November 16, 1942






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.