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Journal of Pharmacology And Experimental Therapeutics, Vol. 77, Issue 3, 220-228, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

STUDIES ON VERATRUM ALKALOIDS

II. THE ACTION OF VERATRIDINE AND CEVINE UPON THE ISOLATED MAMMALIAN HEART

GORDON K. MOE 1 and OTTO KRAYER 1

1 From the Department of Pharmacology, Harvard Medical School, Boston, Mass.

The cardiac action of the two pure veratrum alkaloids veratridine and cevine, and of veratric acid, was studied in the heart-lung preparation of the dog. Both alkaloids share the characteristic action upon the heart muscle which leads to an increase in the work of the heart, particularly in experimental heart failure. The effective and therapeutic doses are reported. Veratridine, which is an ester of cevine and veratric acid, is about 300 times more potent than cevine. Veratric acid is devoid of any characteristic action upon the mammalian heart.

Submitted on October 30, 1942






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Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.