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Journal of Pharmacology And Experimental Therapeutics, Vol. 77, Issue 3, 207-214, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

SULFAPYRIDINE BACTERIOSTASIS OF LACTOBACILLUS ARABINOSUS AND ITS COUNTERACTION

L. J. TEPLY 1, A. E. AXELROD 1, and C. A. ELVEHJEM 1

1 From the Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison

1. Sulfapyridine prevents growth of Lactobacillus arabinosus and is completely counteracted by p-amino benzoic acid or high levels of nicotinic acid.

2. In contrast to results obtained in dog studies, fresh and dried liver are equally effective in counteracting sulfapyridine bacteriostasis.

3. A counteracting acid-labile factor (or factors) distinct from p-amino benzoic acid is present in liver extract and grass juice.

4. The non-p-amino benzoic acid fraction shows properties similar to those reported for folic acid preparations.

5. Nicotinamide compounds only partially counteract sulfapyridine and high levels of nicotinamide are inhibitory in the presence of the drug.

6. Sulfaguanidine and sulfasuxidine are less potent than sulfapyridine and are also completely counteracted by p-amino benzoic acid.

Submitted on October 29, 1942






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Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.