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Journal of Pharmacology And Experimental Therapeutics, Vol. 77, Issue 2, 184-193, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

THE ANALGESIC PROPERTIES OF CERTAIN DRUGS AND DRUG COMBINATIONS

DONN L. SMITH 1, MARIE C. D'AMOUR 1, and FRED E. D'AMOUR 1

1 From the Biologic Research Laboratories, University of Denver

A convenient and reasonably accurate method for assaying the analgesic potency of drugs is described and data indicating its reliability are presented. This method was applied to the determination of the analgesic properties of certain drugs and drug combinations, with the following results;

1. Little analgesia is conferred by the ordinary analgesics, (aminopyrine, aspirin, etc.) either alone or in combination, unless very large doses are given. Of these aminopyrine was most effective.

2. Little analgesia is conferred by barbiturates, either alone or in combination with the above group.

3. A considerable degree of potentiation of the analgesic properties of morphine and codeine is obtained by using aminopyrine, cyclopal (a barbiturate) either alone or, better, together, in combination with the opiate. This potentiation is greater when the agents are given intraperitoneally than orally. Magnesium sulfate with cyclopal is also effective.

4. It is quite possible that even better results might be achieved with other combinations or dosages.

Submitted on October 19, 1942




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