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Journal of Pharmacology And Experimental Therapeutics, Vol. 77, Issue 2, 180-183, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

METABOLISM OF HYDANTOIN DERIVATIVES CLOSELY RELATED TO DILANTIN

C. H. HINE 1 and F. L. KOZELKA 1

1 From the Department of Pharmacology and Toxicology, University of Wisconsin, Madison

Excretion studies on the degradation products, which so far have been identified as coming from dilantin and hydantoin derivatives closely related to dilantin, are presented. The acetyl group in the 1 position, the sulfur in the 2 position, and the methyl group in the 3 position have no effect on the stability of the hydantoin molecule in vivo. On the other hand, methoxy groups in the para positions of the benzene rings of dilantin appear to render the molecule less stable, while an ethyl group in the 5 position in place of one of the phenyl groups renders the molecule more stable.

Submitted on October 16, 1942






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Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.