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Journal of Pharmacology And Experimental Therapeutics, Vol. 77, Issue 2, 175-179, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

DEGRADATION PRODUCTS OF DILANTIN

F. L. KOZELKA 1 and C. H. HINE 1

1 From the Department of Pharmacology and Toxicology, University of Wisconsin, Madison

The metabolism of 5,5 diphenylhydantoin (dilantin) was investigated. It was found that in man and dog approximately 1 to 4% of the drug is excreted unchanged, 1 to 5% as the hydantoic acid, and 10 to 27% as alpha amino diphenyl acetic acid. Only 30 to 35% of the administered drug could be accounted for.

Submitted on October 16, 1942






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Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.