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Journal of Pharmacology And Experimental Therapeutics, Vol. 77, Issue 2, 151-153, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF SODIUM CITRATE ADMINISTRATION ON EXCRETION OF LEAD IN URINE AND FECES

T. V. LETONOFF 1 and SEYMOUR S. KETY 1

1 From the Division of Biochemistry of the Laboratories of Philadelphia General Hospital, Philadelphia, Pa.

The excretion of lead in urine and feces of 9 patients after long-continued exposure to lead was determined before and during the administration of sodium citrate. Appreciable increases in urinary, fecal and total excretion in 8 of the 9 cases occurred during citrate therapy. The mean increase in total excretion of lead during citrate therapy for all 9 cases is statistically significant.

Submitted on October 7, 1942






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Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.