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Journal of Pharmacology And Experimental Therapeutics, Vol. 77, Issue 2, 143-150, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

NOBLE-COLLIP SHOCK: THERAPEUTIC EFFECTS WITH AUTONOMIC DEPRESSANTS; MOTION FACTORS

PAUL A. ZAHL 1, S. H. HUTNER 1, and F. S. COOPER 1

1 From the Haskins Laboratory, 305 East 43rd St., New York City

Atropine, scopolamine, light anesthesia, abdominal binding, and conditioning by previous tumbling were treatments found to be effective in protecting rats against lethal damage induced by tumbling in the Noble-Collip apparatus. Physostigmine sensitized animals to Noble-Collip damage. These and other therapeutic data emphasize the involvement of cholinergic components of the autonomic nervous system in such damage.

The involvement of the parasympathetic nervous system, considered in relation to factors involved in the violent tumbling characteristic of the Noble-Collip procedure, suggests that the acceleration-deceleration effect is an important component of Noble-Collip injury. Confirmation of this view was obtained by subjecting rats to rapid up-and-down shaking in a device designed to eliminate the type of gross trauma induced by Noble-Collip tumbling. Measures found effective in protecting rats from damage due to tumbling were also effective against shaking.

Submitted on September 23, 1942






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Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.