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Journal of Pharmacology And Experimental Therapeutics, Vol. 77, Issue 2, 123-126, 1943
Copyright © 1943 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF COCAINE, ERGOTAMINE AND YOHIMBINE ON THE ACTIVITY OF PHENOL SULFUR ESTERASE

CLARA TORDA 1

1 From the Department of Pharmacology, Cornell University Medical College, New York City

1. The effect of cocaine, ergotamine and yohimbine on the activity of the phenol sulfur esterase has been investigated.

2. Cocaine inhibits the activity of this enzyme while ergotamine and yohimbine increase it.

3. This study suggests that the inactivation of the phenol sulfur esterase is one mechanism by which cocaine potentiates the action of epinephrine, and a potentiation of the activity of phenol sulfur esterase is one mechanism by which ergotamine or yohimbine depress the action of epinephrine.

Submitted on September 16, 1942






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Copyright © 1943 by the American Society for Pharmacology and Experimental Therapeutics.