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Journal of Pharmacology And Experimental Therapeutics, Vol. 76, Issue 4, 375-377, 1942
Copyright © 1942 by American Society for Pharmacology and Experimental Therapeutics

TOXICITY OF BENZEDRINE SULFATE IN THE WHITE MOUSE AND IN THE FROG (CALYPTOCEPHALUS GAYI)

B. GÜNTHER 1

1 From the Institute of Physiology, University of Concepción, Chile

(1) In white mice benzedrine poisoning produced signs of nervous hyperexcitability, while in frogs there was immediate diminution and eventual disappearance of all reflexes in a certain definite sequence.

(2) The LD50 of benzedrine sulfate in white mice was 270 mgm. per kgm. by subcutaneous injection. Injected into the ventral lymph sac of frogs, it was 280 mgm. per kgm.

Submitted on August 29, 1942






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Copyright © 1942 by the American Society for Pharmacology and Experimental Therapeutics.