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Journal of Pharmacology And Experimental Therapeutics, Vol. 76, Issue 4, 358-362, 1942
Copyright © 1942 by American Society for Pharmacology and Experimental Therapeutics

THE TRYPANOCIDAL ACTION OF 3-AMINO-4-HYDROXYPHENYL ARISENIOUS OXIDE ("MAPHARSEN") ADMINISTERED ORALLY WITH GLUTATHIONE

SANFORD M. ROSENTHAL 1

1 Sr. Pharmacologist, Division of Chemotherapy, National Institute of Health, United States Public Health Service

3-Amino-4-hydroxyphenyl arsenious oxide administered by mouth possesses curative action against Trypanosome equiperdum infections in mice.

The addition of 2 moles of glutathione decreased toxicity without affecting therapeutic activity, giving a therapeutic ratio that compares favorably with intravenous administration.

Preliminary experiments indicate some therapeutic action in rabbit syphilis following oral therapy.

Submitted on August 24, 1942




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SPHILIS: A REVIEW OF THE RECENT LITERATURE
Arch Intern Med, November 1, 1943; 72(5): 635 - 706.
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Copyright © 1942 by the American Society for Pharmacology and Experimental Therapeutics.