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Journal of Pharmacology And Experimental Therapeutics, Vol. 76, Issue 4, 355-357, 1942
Copyright © 1942 by American Society for Pharmacology and Experimental Therapeutics

METABOLISM, TOXICITY AND MANNER OF ACTION OF GOLD COMPOUNDS USED IN THE TREATMENT OF ARTHRITIS

IV. STUDIES OF THE ABSORPTION, DISTRIBUTION AND EXCRETION OF GOLD FOLLOWING THE INTRAMUSCULAR INJECTION OF GOLD THIOGLUCOSE AND GOLD CALCIUM THIOMALATE

WALTER D. BLOCK 1, OLIVER H. BUCHANAN 1, and R. H. FREYBERG 1

1 From the Rackham Arthritis Research Unit Medical School, University of Michigan, Ann Arbor

(1) Following the intramuscular injection of oily suspensions of gold calcium thiomalate and gold thioglucose in the white rat the rate of absorption of gold is somewhat faster in the case of the latter compounds.

(2) Gold was found in larger amounts in the kidneys and liver than in other tissues studied.

(3) Excretion occurs through both the kidneys and gastro-intestinal tract. The chief route of excretion of the soluble gold thioglucose is the kidneys while gold is excreted primarily in the feces following administration of the insoluble gold calcium thiomalate.

Submitted on August 20, 1942




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L. T. SWAIM
PROGRESS IN ORTHOPEDIC SURGERY FOR 1943 A REVIEW PREPARED BY AN EDITORIAL BOARD OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS: XIV. CHRONIC ARTHRITIS
Arch Surg, November 1, 1944; 49(5): 357 - 362.
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Copyright © 1942 by the American Society for Pharmacology and Experimental Therapeutics.